Changes of RV-PC coupling during negative for myocardial ischemia dobutamine stress echocardiography

Abstract Background Coupling between RV contractile function and pulmonary circulation (PC) reflects the comprehensive performance of by integrating afterload contractility. RV-PC coupling is nowadays frequently expressed non-invasively measured ratios TAPSE/RVSP RVFWLS/RVSP. It has been shown that it decreases slightly during exercise, whereas no known data exist on how dobutamine does affect it. Purpose The aim this study was to evaluate changes in mechanics different stages stress echocardiography (DSE) cases without coronary artery disease (CAD) negative for myocardial ischemia DSE. Methods Patients with a low-to-intermediate risk CAD were referred underwent systolic evaluated TAPSE, S' Free Wall (RVFW) Strain. indexing TAPSE free wall longitudinal strain right ventricular pressure (RVSP) baseline echocardiogram, low dose (inotropic effect) peak (chronotropic Results Initially, total 53 patients Eight had positive response excluded. remaining 45 {mean age 65±8.7, 28 (63%) male}, 24 (53%) hypertension, smokers, 33 (74%) dyslipidemia, 15 (34%) family history 7 (15%) diabetes mellitus. RVFW Strain increased from [23.55±2.91 vs 28.76±1.9 (p<0.001), 13.13±1.79 23.83±4.87 (p<0.001) 19.7±5.87 23.46±5.42 (p=0.044) respectively]. showed significant steady decrease (0.88±0.14 0.79±0.19) 0.74±0.12) difference 0.09 (p value 0.013) 0.14 0.000) respectively. On other hand, Strain/ RVSP exhibited (0.60±0.15, p only dose. There correlation change E/E' or Systolic Blood Pressure. Conclusions DSE independently LV dynamic therefore, future studies should be oriented incremental role novel index not assessment evaluation affects coupling, but also as prognostic marker evident ischemia. Funding Acknowledgement Type funding sources: None.